World's first publication on this particular topic and a basic guide for students related to calculus with basic steps in MATLAB, R, and Python. This ebook covers the following subtopics: • Basic introduction to Calculus • Computational BioCalculus • Definitions • Functions • Linear functions – Linear Models • Limits • Differential Calculus • Derivatives • Partial Derivatives • Slope • Maximum and minimum values • Maxima and minima in images • Finding maxima and minima (peaks) in an ECG • Optimization • Integral Calculus • Integrals • Plotting a graph with the information of slope or “rate of change” • Area under the curve • Differential Equations • Differential equation consisting of one variable