Design and Development of Carvedilol Phosphate Floating Microsphere: Formulation and in-vitro Evalution of Carvedilol Phosphate Floating Microsphere

by Pranav Joshi

Carvedilol has unique pharmacological profile. It blocks β1, β2, and α1 receptors, used in the management of hypertension and as an adjunct to standard therapy in symptomatic heart failure and also produces vasodilation. In the present study, an attempt has been made to improve drug concentration in the stomach by preparing gastroretentive floating microsphere of carvedilol phosphate to maintain drug levels within a desired range, reduce dosing frequency, Improve patient compliance, improve dissolution and at the site of absorption.Drug molecules presenting no difficulties in their solubility and/or absorption problems are good candidates for oral controlled release formulations but Obstacle may arise for many drugs related to their solubility and/or absorption that may be overcome by formulating Gastroretentive systems which prolong the gastric retention time, improves solubility and hence improves bioavailability for drugs that are less soluble in a high pH environment.

144 pages, Paperback

Published June 7, 2013

About the author

Started my reading journey with evergreen classics Enid Blyton and Sidney Sheldon around 7th/8th grade.
Post that came the fantasy/mythology Rick Riordan/Ashwin Sanghi phase in 10th.
Then got very deeply into Dan Brown's works around my 11th/12th.
In my B.Com degree, read a whole lot of non fiction, which taught me how to think and function better.
Today, as a full time employee of a global bank, I consciously carve out time to read fiction to relax and read people's stories, and sometimes non-fiction to keep myself upgraded.

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