“Isabella did not lack for occupation, and had plenty of projects between the embellishment of her art collection and, during Francesca’s absences, the running of Mantua. The worsening situation as Cesare Borgia greedily took the weaker Romagnal states, as well as there being two French invasions, had left Isabella as regent of her husband’s small but important state for much of her married life. During that critical period, which required supreme diplomacy, she feared that her husband, a creature not gifted with the necessary slippery talents, could cause real harm to the couple and their state with one of his ill-tempered and overly frank outbursts.”