“He experienced a range of intense and unpleasant side effects [on puberty blockers], as he tried different doses. ‘On one of them I had really bad insomnia. And another one, I had really bad anger problems.’ … ‘Your mood goes like it’s a roller coaster,’ he explains. ‘There are moments when you’re euphorically happy. The next day, you crash really bad and you are exhausted. And then you’re really, really depressed, like, suicidal depressed.’ Jacob says he had felt depressed before starting on puberty blockers and had experienced anxiety… ‘On the blockers I broke my wrist twice, my knuckles, my toe. It really ruins your bone density.’ Four broken bones in just a few years…As Jacob’s health deteriorated and his puberty continued to ‘break through’, he grew increasingly distressed…After more than four years on the blocker, Jacob felt worse than he ever had before the medication. While his friends were getting their first boyfriends and girlfriends, experiencing their first kisses and sexual experiences, he felt nothing. ‘You have no desire, no drive whatsoever,’ he says. ‘You don’t even feel attracted to people.’ … Emotionally, he felt years younger than his peers. Michelle noticed it too. And physically, Jacob had stopped growing.”