Ashton Lee
Ashton Lee asked Stuart Gibbs:

Are Esmerelda Castello and Dane Brammage related? After all, the Castellos can't feel pain and pain doesn't seem to bother Dane either. In Charlie Thorne and the Lost City, Charlie says that there is a specific Italian family with that gene and a Pakistani family. Based on the fact that Dane has natural blond hair, I find it likely he would be Italian like the Castellos.

Stuart Gibbs They are not related. Dane's imperviousness to damage is a joke and not really possible, whereas Esmerelda's is based on an actual family and is played more realistically. Also, Dane is Scandanavian.

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